Mild kidney dysfunction affects the predictive accuracy of blood-based biomarkers for neuropsychological and neuroimaging outcomes over a 9 year follow-up period.

ABSTRACT:

Introduction

The impact of chronic kidney disease (CKD) on Alzheimer's disease (AD) plasma biomarkers is poorly understood. We tested whether kidney function decline affects the predictive accuracy of plasma biomarkers on neuropsychological or neuroimaging outcomes.

Methods

Three hundred thirty-three non-demented older adults were included. Linear regressions related plasma glial fibrillary acidic protein, neurofilament light chain (NfL), amyloid beta 42, and phosphorylated tau₂₃₁, with a blood-based biomarker x estimated glomerular filtration rate (eGFR) interaction term, to cross-sectional and longitudinal (mean follow-up time = 6.4 ± 2.8 years) neuropsychological and neuroimaging outcomes.

Results

Plasma NfL interacted with eGFR on the longitudinal traje

SUBMITTER: Bolton CJ 

PROVIDER: S-EPMC12447110 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature