Cryoneurolysis for Managing Spasticity in Multiple Sclerosis: A Case Report Demonstrating Sustained Functional Gains and Cost-Effectiveness.

ABSTRACT: Cryoneurolysis is a minimally invasive procedure that induces secondary axonotmesis while preserving the nerve's supportive structures, offering an alternative approach to managing spasticity in multiple sclerosis (MS)-a condition affecting up to 90% of patients with MS and often leading to contractures, pain, and reduced mobility. In this case report, a 48-year-old woman with progressive MS who previously experienced side effects and limited benefits from prior botulinum toxin-A injections underwent ultrasound-guided percutaneous cryoneurolysis on targeted nerves to spastic muscles identified using the response to diagnostic nerve blocks. Range of motion and spasticity were assessed using the Modified Ashworth Scale, Modified Tardieu Scale, and numerical pain ratings. The patient demonstr

SUBMITTER: Hughes A 

PROVIDER: S-EPMC12447202 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature