Association between base excess level at hospital arrival and neurological outcomes in adult out-of-hospital cardiac arrest: A multicentre cohort study.

ABSTRACT:

Aim

We aimed to assess the association between base excess (BE) levels and neurological outcomes in patients with out-of-hospital cardiac arrest (OHCA), accounting for the time from cardiac arrest onset to blood sampling.

Methods

This multicentre study was conducted in Osaka, Japan, and enrolled consecutive patients with OHCA who were transported to 16 medical centres between 2012 and 2021. Patients aged ≥ 18 years with witnessed OHCA and available BE measurements upon hospital arrival were examined. Patients were stratified into Q1 (BE ≤ -21.1 mmol/L), Q2 (-21.1 < BE ≤ -15.7 mmol/L), Q3 (-15.7 < BE ≤ -10.4 mmol/L) and Q4 (BE > -10.4 mmol/L) groups based on BE levels. The primary outcome was 1-month survival with a favourable neurological outcome (Cerebral Performance Catego

SUBMITTER: Onodera R 

PROVIDER: S-EPMC12447215 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature