Early Blood Pressure Targets in Acute Spinal Cord Injury: A Randomized Clinical Trial.

ABSTRACT:

Importance

Early blood pressure management is central to neurologic resuscitation of spinal cord injury; however, the role of augmented blood pressure is unclear.

Objective

To compare the efficacy and safety of augmented vs conventional blood pressure on 6-month neurologic outcomes after acute spinal cord injury.

Design, setting, and participants

This multicenter randomized clinical trial took place from October 3, 2017, to July 26, 2023, and assessed patients 18 years or older with spinal cord injury followed up for 6 months at 13 large US trauma centers.

Interventions

Patients were equally randomized to augmented (>85-90 mm Hg) or conventional (>65-70 mm Hg) mean arterial pressure for 7 days or until intensive care unit discharge.

Main outcomes and measure

SUBMITTER: Sajdeya R 

PROVIDER: S-EPMC12447234 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature