Orbitofrontal Gray-White Interface Injury and the Association of Soccer Heading With Verbal Learning.

ABSTRACT:

Importance

Sport-related repetitive head impacts (RHIs) are linked to structural and functional brain changes and may be associated with risk for neurodegenerative disease. However, the locus of RHI-associated pathology that leads to adverse cognitive performance has yet to be characterized in vivo.

Objective

To examine whether orbitofrontal gray matter-white matter interface (GWI) microstructure is associated with soccer RHI and whether it mediates the association of RHI with cognitive performance.

Design, setting, and participants

This cross-sectional study, performed at Albert Einstein College of Medicine and Columbia University Irving Medical Center, included a population-based sample from the greater New York City area of amateur soccer players aged 18 to 55 year

SUBMITTER: Song JY 

PROVIDER: S-EPMC12447236 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature