Lack of immunogenicity for an influenza-derived peptide across the HLA-B44 supertype molecules.

ABSTRACT:

Objectives

CD8⁺ T cells are protective against influenza and there is an interest in designing a future CD8⁺ T-cell-mediated vaccine. However, a significant challenge is the extensive polymorphism of Human Leukocyte Antigen class I (HLA-I) molecules, the targets of CD8⁺ T cells. Despite this, HLA supertypes have been defined as a subset of HLA-I molecules sharing similar peptide motif preferences that may present overlapping peptide repertoires. Therefore, selecting immunogenic peptides presented by a range of HLA-I molecules for inclusion in a vaccine may partially overcome the challenge presented by HLA-I polymorphism.

Methods

In this study, we investigated the presentation and immunogenicity of a known HLA-B*44:03-restricted influenza-deri

SUBMITTER: Leong SL 

PROVIDER: S-EPMC12447248 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature