Real-world clinical outcomes of patients with high-risk endometrial cancer or endometrial carcinosarcoma in England: A retrospective cohort study.

ABSTRACT:

Aim

The objectives of this study were to describe patient characteristics and estimate real-world disease-free survival (rwDFS) and overall survival (OS) from initiation of first adjuvant therapy among patients with high-risk endometrial cancer (EC) in England.

Methods

This was a retrospective cohort study based on data from Public Health England's National Cancer Registration and Analysis Service (NCRAS) between 2014 and 2023. Adult women with EC or endometrial carcinosarcoma at high risk of recurrence who received adjuvant therapy within 90 days after surgery were eligible for inclusion. We operationalized rwDFS as time to next treatment or death.

Results

In total, 6036 women (mean age: 67 years; 86% White) were eligible for inclusion, with a mean follow-up of 48 mo

SUBMITTER: Prabhu VS 

PROVIDER: S-EPMC12447258 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature