A highly sensitive photoelectrochemical immunosensor for cancer antigen (CA 125) based on a nanoplatform of carbon dots and cadmium sulphide.

ABSTRACT: The prognosis for ovarian cancer is often poor due to late diagnosis. This is because the disease rarely presents with any specific symptoms in the early stage. There is therefore a need to develop a sensitive device for the routine screening of CA 125, the most widely used biomarker for detecting and monitoring ovarian malignancy. Herein, we report the development of a photoelectrochemical (PEC) immunosensor based on a screen-printed carbon electrode (SPCE) modified with a carbon nanodot/cadmium sulphide (CND/CdS) heterostructure for the sensitive detection of CA 125. Using a drop-casting technique and a self-assembly process, the immunosensor was constructed by the successive immobilization of CND, CdS, an N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (NHS-EDC

SUBMITTER: Ekwujuru EU 

PROVIDER: S-EPMC12447262 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature