A pan-cancer perspective analysis reveals the prognostic significance of SLC7A11 in hepatocellular carcinoma.

ABSTRACT:

Background

The cystine/glutamate antiporter SLC7A11 is critically involved in tumorigenesis andferroptosis regulation. However, its comprehensive role in hepatocellular carcinoma (HCC) prognosis and tumor immunity remains elusive.

Methods

We evaluated SLC7A11 expression using immunohistochemistry (IHC) in a clinical HCC cohort and analyzed its prognostic significance. A pan-cancer analysis across The Cancer Genome Atlas (TCGA) datasets was performed to investigate SLC7A11 genetic alterations, its impact on the tumor microenvironment (TME), tumor mutation burden (TMB), and therapy response.

Results

SLC7A11 was significantly upregulated in HCC tissues, and high expression predicted poorer overall survival. Pan-cancer analysis confirmed its aberrant expression and identi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12447273 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature