Volumetric Changes and Acute Toxicity With ⁶⁸Ga Prostate-Specific Membrane Antigen Versus ¹⁸F-Fluciclovine Positron Emission Tomography/Computer Tomography Guided Postprostatectomy Radiation: Final Analysis of a Randomized Trial.

ABSTRACT:

Purpose

We evaluated changes in radiation therapy target volume and acute toxicity using ⁶⁸Ga-prostate specific membrane antigen (PSMA) versus ¹⁸F-fluciclovine positron emission tomography (PET)/computed tomography in postprostatectomy patients with biochemical recurrence. We hypothesized that both fluciclovine and PSMA-guided radiation therapy would (1) significantly change pre-PET radiation therapy volumes and (2) show similar toxicity.

Methods and materials

We performed an institutional review board-approved, randomized trial comparing fluciclovine (Arm 1) and PSMA (Arm 2)-guided postprostatectomy radiation therapy in patients with detectable prostate-specific antigen after prostatectomy. Treatment volumes were rigidly defined based on PET, and simul

SUBMITTER: Dhere VR 

PROVIDER: S-EPMC12447277 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature