Incidence and Outcomes of Head and Neck Cancer in Patients With Schizophrenia.

ABSTRACT:

Objective

We sought to determine the incidence and outcomes of head and neck cancer (HNC) among patients with schizophrenia.

Study design

Cohort study utilizing TriNetX, a database containing millions of deidentified clinical records.

Setting

Multicenter study utilizing records from 68 healthcare organizations.

Methods

A cohort of patients with schizophrenia was analyzed for the annual incidence of HNC diagnosis between 2011 and 2021. TriNetX was queried for adult patients with HNC with and without schizophrenia (or long-term antipsychotic use, as a surrogate). Cohorts were 1:1 propensity-matched based on sociodemographic variables to produce matched cohorts of 25,077 patients each. Outcomes included mortality, recurrence in lymph nodes and lung, systemic treat

SUBMITTER: Wenger TA 

PROVIDER: S-EPMC12447352 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature