Biofilm Eradication Using Water-Soluble Silver(I) Coumarin Complexes.

ABSTRACT: Water-soluble photostable coumarin acetate complexes of silver(I) are successfully synthesized and characterized and found to have the ability to eradicate preformed MRSA biofilms. Substitution with short PEG chains at the 4-position of the coumarin ring allows the subsequent synthesis of water-soluble coumarin oxyacetate ligands which successfully allowed silver(I) complex formation. The new complexes are characterized by IR and NMR spectroscopy, microanalysis and high-resolution mass spectrometry where possible. Previous unPEGylated analogs has shown excellent antimicrobial activity against the pathogenic bacteria MRSA, Escherichia coli and Pseudomonas aeruginosa and that activity is maintained in the PEGylated complexes. However, the solubility of the un-PEGylated analogs is limited to

SUBMITTER: Mooney E 

PROVIDER: S-EPMC12447374 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature