Multifunctional Hybrid Membrane-Coated Nanomotors for Magnetically Guided, Cascade-Activated Chemoimmunotherapy for Triple-Negative Breast Cancer.

ABSTRACT: Here, we report a multifunctional hybrid membrane-coated nanomotor for cancer chemoimmunotherapy, which consists of mesoporous silica-coated iron oxide nanoparticles (MF) as a drug carrier, loaded with doxorubicin (DOX), l-arginine (l-arg), and glucose oxidase (GOx), and camouflaged with a hybrid of red blood cell membranes (mRBC) and cancer cell membranes (CCM). RM-GDL-MF has a cascade of catalytic reactions, where glucose is catalyzed by GOx to produce H₂O₂, and l-arg is oxidized by the produced H₂O₂ to release nitric oxide (NO), leading to self-propelled motion in order to promote the penetration of the extracellular matrix (ECM) in the tumor. The hybrid membrane provides not only stealth properties from mRBC to evade immune clearance but also

SUBMITTER: Lee ML 

PROVIDER: S-EPMC12447376 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature