Dual Stimuli-Responsive Gemcitabine-Conjugated Alginate-Chitosan Nanoparticles for Triple-Negative Breast Cancer Therapy: A Smart Approach.

ABSTRACT: Among the available chemotherapeutic agents, gemcitabine (GEM) has demonstrated significant efficacy against various cancers. Nevertheless, its clinical application is restricted due to its poor pharmacokinetic properties, highlighting the need for improved drug delivery strategies. Here, Dual stimuli-responsive hybrid polymeric nanoparticles conjugating GEM have been developed using a chitosan alginate biopolymer. The polymers anchored GEM via hydrazone and disulfide linkers, enabling dual stimuli-responsive drug release in tumors by leveraging pH variations and elevated glutathione (GSH) levels. This innovative nanoplatform enhances GEM systemic exposure, stability, and therapeutic efficacy while minimizing systemic toxicity. The Alg/Chi-GEM nanoparticles (NPs) were comprehensively chara

SUBMITTER: Patel T 

PROVIDER: S-EPMC12447381 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature