Prognostic impact of focal lesion location and persistence in multiple myeloma: insights from serial PET/DWI imaging.

ABSTRACT:

Abstract

Multiple myeloma (MM) is a heterogeneous disease exemplified by focal lesions (FLs), densely populated nodules whose number and persistence during treatment predict poor outcome. However, the prognostic role of FL location and the relationship between FLs at different time points remain underexplored, although they may provide critical clues to disease evolution and resistance mechanisms. We analyzed positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI) scans from 243 patients with MM enrolled in total therapies at baseline, after autologous stem cell transplant (ASCT), and every 6 to 12 months thereafter until relapse or last follow-up. Baseline FLs in the humerus or femur were associated with poor prognosis. Although rare, residual PE

SUBMITTER: Schinke C 

PROVIDER: S-EPMC12447427 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature