The OHI index predicts early mortality from organ dysfunction and survival benefit from etoposide in patients with lymphoma.

ABSTRACT:

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome that complicates hematologic malignancies. The Optimized HLH Inflammatory (OHI) index, based solely on the combined elevation of soluble CD25 (sCD25; >3900 U/mL) and ferritin (1000 ng/mL) levels, predicts mortality more effectively than the conventional HLH criteria. This study aimed to determine whether mortality in OHI-positive (OHI+) patients is primarily caused by lymphoma or inflammation-related causes. In a multicenter, retrospective study of patients with newly diagnosed lymphoma with sCD25 and ferritin measurements available, patients were classified as OHI+ or OHI negative (OHI-). The 1-year and 3-year overall survival (OS), event-free survival, and causes of death were analyzed, along with p

SUBMITTER: Zoref-Lorenz A 

PROVIDER: S-EPMC12447441 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature