Changes in psychopathology and peripheral inflammation in schizophrenia patients initiating treatment with second-generation antipsychotics: a post-hoc analysis.

ABSTRACT: Neuroinflammation has been proposed as a potential factor in the pathogenesis of schizophrenia and has been suggested to be both a state and a trait measure of the disease. However, the results of previous studies are inconsistent. The aim of the present study was therefore to investigate whether peripheral inflammatory markers such as C-reactive protein (CRP), the neutrophil-to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), and the systemic immune-inflammation index (SII) can reliably indicate disease severity in schizophrenia. 116 (52.6% male) cases diagnosed with schizophrenia commencing monotherapy with a second-generation antipsychotic were included in this study. Next to baseline evaluation of sociodemographic and clinical data, the Positive and Negative Syndrome Sca

SUBMITTER: Heil M 

PROVIDER: S-EPMC12447443 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature