Literature review and case study of predominant tubulointerstitial lupus nephritis.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that affects multiple organ systems, and lupus nephritis (LN) primarily involves glomerular, vascular and tubulointerstitial lesions. Renal tubulointerstitial lesions are almost always present alongside glomerular lesions, with isolated renal tubulointerstitial LN being very rare. The aim of this study was to evaluate the clinicopathological features, differential diagnosis, treatment and prognosis of predominant tubulointerstitial lupus nephritis (PTILN).

Case presentation

We present the case of a 64-year-old Chinese male with severe SLE. The diagnosis of SLE was confirmed on the basis of proteinuria, positive antinuclear antibodies, and immunological and haematological disorders. Renal biopsy r

SUBMITTER: Wang J 

PROVIDER: S-EPMC12447453 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature