Divalent and Trivalent Metallic Ions Differentially Affect Alpha-Synuclein Aggregation.
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ABSTRACT: Alpha-synuclein (αSyn) is the constituent protein associated with neurodegenerative synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Recent studies have highlighted the potential role of altered metal ion homeostasis in influencing the aggregation and pathological behavior of αSyn, thereby affecting disease progression. We examined αSyn aggregation propensity in the presence of calcium (Ca2+), magnesium (Mg2+), copper (Cu2+), zinc (Zn2+), iron (Fe3+), and aluminum (Al3+). Recombinant αSyn was subjected to in vitro aggregation assays at varying metal ion concentrations. Our findings revealed distinct effects of metal ions on the aggregation kinetics of αSyn: most divalent
SUBMITTER: Graves NJ
PROVIDER: S-EPMC12447500 | biostudies-literature | 2025 Sep
REPOSITORIES: biostudies-literature
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