Harnessing Dynamic Heteroleptic Complexation for Self-Assembly of Robust Nested Metallo-Supramolecular Cages.

ABSTRACT: The exclusive formation of artificial multicomponent assemblies remains a significant challenge, in contrast to the well-established organization observed in natural systems, due to intrinsic entropic constraints. To overcome this limitation, recent efforts have been focused on developing precision self-assembly strategies for the rational construction of such architectures. Here, we construct an ideal complementary pair of 2,2':6',2″-terpyridine (tpy)-based ligands by fine-tuning the substituent bulkiness, which enables the quantitative formation of robust nested cages through efficient dynamic heteroleptic complexation with multivalent coordination. The multivalent ligand design proves essential for successful self-assembly, as the smaller incarcerated cage cannot be independently synthe

SUBMITTER: Prusty S 

PROVIDER: S-EPMC12447513 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature