Stability of Acetals/Ketals Under Controlled Radical and Ring Opening Polymerization.

ABSTRACT: Well-defined acid-degradable amphiphilic block copolymers (ABPs) and their nanoassemblies labeled with acid-labile groups have been developed for smart drug delivery, exhibiting controlled/enhanced release of therapeutics in tumoral tissues and endo/lysosomes. In general, controlled polymerization techniques, particularly atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP) have been utilized to synthesize poly(ethylene glycol)-based ABPs labeled with acetals and ketals. Despite comprehensive studies on their acid-catalyzed hydrolysis rate with substituents attached to oxygen atoms, the stability of the groups under ATRP and tin-catalyzed ROP conditions have been rarely studied. Herein, we report our investigation with benzaldehyde acetal (BzAc) as a typical ac

SUBMITTER: Andrade-Gagnon B 

PROVIDER: S-EPMC12447677 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature