Polyesteracetals via TBD Catalyzed Ring-Opening Polymerization.

ABSTRACT: Polyacetals represent a novel category of degradable polymers, exhibiting remarkable potential for utilization in biomedical and pharmaceutical applications due to their controllable degradation behavior under physiological conditions. The organocatalyst 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was used for the ring-opening polymerization (ROP) of 2-methyl-1,3-dioxane-4-one. Whereas standard reaction conditions, suitable for lactide polymerization resulted in a polyester due to loss of acetaldehyde, the amount of esteracetal repeating units could be tailored by the polymerization conditions. Performing the ROP at -35°C at a monomer concentration of 15 mol L^-1 maximized the incorporation of labile acetal groups to 50 mol%. The versatility of this polymerization system was demons

SUBMITTER: Meyer J 

PROVIDER: S-EPMC12447686 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature