Multifaceted photocatalysis enables cobalt catalyzed enantioselective C-H activation and APEX reaction for C-N axially chiral molecules.

ABSTRACT: Molecules with the C-N stereogenic axes have widespread applications, yet their asymmetric synthesis under mild and environmentally friendly conditions is becoming increasingly challenging. Herein, we report the merger of inexpensive photoredox catalysis with a cobalt-catalyzed asymmetric C-H activation/APEX strategy, enabling cascade annulation of (hetero)arenes and alkenes with α-aryl-allenyl acetates to deliver C-N axially chiral benzophenanthridinone and polycyclic quinolinone frameworks with very high yields and enantioselectivities at room temperature. This methodology leverages the multifaceted role of photocatalysis - facilitating the redox event of the cobalt catalyst and the formation of key intermediates that drive the APEX process. It also harnesses the α-aryl-allenyl acetate c

SUBMITTER: Koner M 

PROVIDER: S-EPMC12447758 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature