Aging and Gender Modify the Risk of Carotid Plaque Thrombosis Related to Dyslipidemic Profile.

ABSTRACT:

Background

Dyslipidemia plays a critical role in carotid plaque instability and related cerebrovascular events. Reduction of low-density lipoprotein cholesterol (LDL-C) levels decreases ischemic stroke risk; however, a residual cardiovascular risk persists. Starting from this evidence, this study evaluated the impact of dyslipidemia on carotid plaque instability while also considering age and gender.

Methods

In this observational study, a total of 354 carotid plaques from symptomatic and asymptomatic patients undergoing endarterectomy were analyzed histologically. Dyslipidemic profiles, including high LDL-C, remnant cholesterol, triglycerides, and low high-density lipoprotein cholesterol, were assessed alongside other risk factors. Logistic regression identified independent

SUBMITTER: Servadei F 

PROVIDER: S-EPMC12447824 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature