Landscape of genomic alterations and clinical outcomes in low-grade serous ovarian cancer in Korea.

ABSTRACT:

Introduction

To investigate the clinical characteristics, molecular findings, and survival outcomes of patients with low-grade serous ovarian cancer in Korea, with a focus on addressing the limited data on genetic profiling and targeted therapies in Asian populations.

Methods

This study is a retrospective review of patients with pathologically confirmed LGSOC treated at the National Cancer Center Korea between 2010 and 2023. Patients underwent cytoreductive surgery and/or systemic or hormonal therapy. Molecular profiling included next-generation sequencing (NGS) of formalin-fixed, paraffin-embedded tumor samples and homologous recombination deficiency (HRD) testing. Survival outcomes were assessed using Kaplan-Meier analysis.

Results

A total of 62 patients were includ

SUBMITTER: Shim YS 

PROVIDER: S-EPMC12447911 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature