Kruppel-like factor 4 regulates cellular proliferation and differentiation in human bone marrow-derived mesenchymal stem cells.

ABSTRACT: Mesenchymal stem cells (MSCs) form one of the types of adult stem cell which have the capacity to self-renew, and the multipotentiality for osteogenic, chondrogenic and adipogenic differentiation and immune modulation. Consequently, MSCs are an attractive cell source for regenerative medicine and therapy for inflammatory disease. However, biological criteria to ensure any particular MSCs are "stem cells" have not been clarified. Previously, we reported that MSCs isolated from a single CD90/CD271 double-positive cell in human bone marrow have high colony-forming capacity and tri-lineage differentiation potential in vitro. Such clonal MSCs are highly homogeneous and considered to be useful for the analysis of molecular function. In this study, we focused on Krüppel-like factor 4 (KLF4

SUBMITTER: Miyamoto K 

PROVIDER: S-EPMC12447919 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature