Histone demethylase LSD1 regulates lipid homeostasis during <i>Cryptococcus neoformans</i> infection.

ABSTRACT: An opportunistic fungal pathogen, Cryptococcus neoformans, causes cryptococcal meningitis and is frequently associated with high mortality in immunocompromised individuals. The formation of metabolically altered lipid-rich foamy macrophages is a successful strategy used by various intracellular pathogens to secure a nutrient source and niche within the host. Herein, we elucidate the involvement of macroautophagy, specifically lipophagy, in lipid dysregulation during C. neoformans infection. C. neoformans driven activation of WNT-signaling leads to an aberrant lipid accumulation in host macrophages under the regulatory role of a histone modifier, Lysine Specific Demethylase 1 (LSD1). In a murine model of pulmonary infection, targeting host LSD1 led to a significant redu

SUBMITTER: Lohia GK 

PROVIDER: S-EPMC12447920 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature