Generation and characterization of vestibular inner ear organoids from human pluripotent stem cells.

ABSTRACT: The inner ear has a pivotal role in auditory and vestibular perception. Despite the vast number of individuals worldwide affected by hearing loss and balance disorders, therapeutic options have been largely limited to technological aids. The recent advent of gene therapies for genetic hearing loss in human patients underscores the urgency of developing scalable platforms to investigate a broader spectrum of inner ear disorders. Although animal models are powerful for assessing auditory and vestibular dysfunction, in vitro human inner ear models have shown promise in disease modeling and as platforms for studying developmental biology. Several studies have demonstrated that stem cells can be guided to differentiate into otic progenitor cells by mimicking environmental cues present during no

SUBMITTER: van der Valk WH 

PROVIDER: S-EPMC12447924 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature