<i>ybx1</i> acts upstream of <i>atoh1a</i> to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts.

ABSTRACT: Like the sensory organs of the human inner ear, the lateral-line neuromasts (NMs) of fish such as the zebrafish (Danio rerio) contain mechanosensory hair cells (HCs) that are surrounded by supporting cells (SCs). A damaged NM can quickly regenerate new HCs by expressing genes such as atoh1a, the master regulator of HC fate, in the SCs at the NM's center. We used the supervised learning algorithm DELAY to infer the early gene-regulatory network for regenerating central SCs and HCs and identified adaptations that promote the rapid regeneration of lateral-line HCs in larval zebrafish. The top hub in the network, Y-box binding protein 1 (ybx1), is highly expressed in HC progenitors and young HCs and its protein can recognize DNA-binding motifs in cyprinids' candidat

SUBMITTER: Reagor CC 

PROVIDER: S-EPMC12447950 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature