Interleukin-6 is associated with high-risk plaque on coronary computed tomography angiography in asymptomatic women.

ABSTRACT:

Background

Coronary high-risk plaque (HRP) is associated with inflammation and adverse outcomes in symptomatic individuals with coronary artery disease (CAD), yet determinants of HRP in asymptomatic individuals without known CAD remain ambiguous.

Objectives

We examined the association between interleukin 6 (IL-6) levels and HRP in asymptomatic women without known CAD and hypothesized higher IL-6 levels will be associated with HRP.

Methods

We measured serum IL-6 levels and performed Coronary Computed Tomography Angiography (CCTA) in 77 women without known CAD enrolled in the Atlanta Women's Interagency HIV Study (median age 54, 92.2% Black, 67.5% living with HIV). Those with spotty calcification, napkin ring sign, low attenuation, or positive remodeling coronary plaque

SUBMITTER: Vatsa N 

PROVIDER: S-EPMC12448042 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature