Thresholds for adjunctive medication usage and probability of initiating injectable naltrexone.

ABSTRACT:

Aims

To estimate the effectiveness of different thresholds for administering opioid withdrawal medications (clonidine and clonazepam) on the probability of successfully initiating extended-release naltrexone (XR-NTX) among participants with opioid use disorder (OUD) during medically managed withdrawal.

Design

Secondary analysis of a multisite clinical trial comparing a rapid vs. standard approach for XR-NTX initiation, 2021-2022.

Setting

Six community inpatient addiction treatment units in the United States.

Participants

English-speaking adults seeking treatment for DSM-5 OUD and expressing interest in XR-NTX treatment (n = 415).

Measurements

We estimated the extent to which the following thresholds for adjunctive medication administration would affect t

SUBMITTER: Rudolph KE 

PROVIDER: S-EPMC12448091 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature