High Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice.

ABSTRACT:

Background

Medial artery calcification and cutaneous arteriolar calcification are prevalent in patients with chronic kidney disease (CKD) and are strongly associated with increased morbidity and mortality. Current experimental CKD models, however, often fail to fully replicate the patterns of medial artery calcification and cutaneous arteriolar calcification, limiting our ability to elucidate their underlying molecular pathways. Developing a reliable experimental model for CKD-associated calcification and using it to identify therapeutic targets is essential for advancing treatment strategies for these vascular complications. In this study, we used a novel strategy that incorporated a high phosphate and low protein diet to promote medial artery and cutaneous vascular calcification

SUBMITTER: Jin Y 

PROVIDER: S-EPMC12448113 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature