A noncanonical role of glycolytic metabolites controlling the timing of mouse embryo segmentation.

ABSTRACT: Studies on the impact of metabolism on cell fate decisions are seeing a renaissance. However, a key challenge remains to distinguish signaling functions of metabolism from its canonical bioenergetic and biosynthetic roles, which underlie cellular homeostasis. Here, we tackled this challenge using mouse embryonic axis segmentation as an experimental model. First, we found that energetically subminimal amounts of glucose can support ongoing segmentation clock activity, providing evidence that glycolysis exerts a signaling function. Using a dynamical systems approach based on entrainment, we identified fructose 1,6-bisphosphate (FBP) as the potential signaling metabolite. Functionally, we demonstrated that glycolytic flux/FBP control the segmentation clock period and Wnt signaling in an antic

SUBMITTER: Miyazawa H 

PROVIDER: S-EPMC12448123 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature