A Bayesian Hierarchical Longitudinal Model for Estimation of Central Visual Field Rates of Change in Glaucoma.

ABSTRACT:

Purpose

Individual visual field (VF) sensitivities become unreliable at threshold sensitivities of 19 dB or less, limiting glaucoma monitoring. We evaluated longitudinal variability of central 10° VF measurements based on baseline sensitivity using a Bayesian hierarchical model.

Methods

We included 124 glaucoma patients (124 eyes) with central or moderate-to-advanced VF damage, more than 2 years follow-up, and more than 4 central 10-2 VF tests. A Bayesian linear model estimated pointwise change rates, compared with simple linear regression (SLR). Simulations modeled average (-0.21 dB/year) and benchmark (-0.5 dB/year) slopes with residual standard deviations (SD) of 2, 4, 7, or 10 dB. Outcomes included pointwise residual SDs and proportions of significant slopes in cohort an

SUBMITTER: Mohammadzadeh V 

PROVIDER: S-EPMC12448127 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature