Ocular and Systemic Risk Factors and Biomarkers for Primary Glaucoma: An Umbrella Review of Systematic Reviews With Meta-Analyses.

ABSTRACT:

Purpose

To synthesize and evaluate the quality of evidence from existing meta-analyses on ocular and systemic factors and biomarkers associated with primary glaucoma.

Methods

Systematic reviews with meta-analysis evaluating ocular and systemic factors or biomarkers of glaucoma were included. Searches of PubMed, Embase, and Cochrane Library were conducted from inception to June 25, 2023, without language restrictions. Two researchers independently conducted screening, data extraction, and quality appraisal. The summary effect size, 95% confidence interval, and 95% prediction interval were estimated by random-effect models. The between-study heterogeneity (I2), evidence of small-study effects, and evidence of excess significance bias were reported. The equivalent standardized

SUBMITTER: Shen RY 

PROVIDER: S-EPMC12448150 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature