Feasibility and efficacy of pH-integrated ultrathin endoscopy for ambulatory gastroesophageal reflux monitoring (with videos).

ABSTRACT:

Background

Current techniques for monitoring gastroesophageal reflux are limited to measuring physicochemical parameters. We presented a novel pH-integrated ultrathin endoscope (the EndoMonitor System) for simultaneous acquisition of reflux images and pH data. This preclinical study evaluated the performance of the latest version of the EndoMonitor System.

Methods

The stability and hydrogen ion selectivity of the pH electrode in the EndoMonitor System were evaluated. Subsequently, six types of reflux events were simulated in an isolated organ (porcine esophagus-stomach). Complete duodenal ligation was used to create porcine gastroesophageal reflux models. The number of reflux episodes and acid exposure time were assessed and compared with the pH-impedance catheter results.

SUBMITTER: Hu X 

PROVIDER: S-EPMC12448187 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature