A virtual knee replacement (vKR) multi-component endpoint for knee osteoarthritis based on patient-reported PROs: Data from the Osteoarthritis Initiative.

ABSTRACT:

Objective

To use patient-reported outcomes (PROs) and performance measures to develop a multi-component outcome (virtual knee replacement [vKR]) that predicts knee replacement (KR).

Methods

Osteoarthritis Initiative (OAI) participants with baseline radiographs, clinical assessments and health insurance were followed for 60 months. Of 8205 knees (4143 participants), 206 knees (187 participants) had KR. Eighteen clinical measures available at annual visits were considered, (e.g., Knee injury and Osteoarthritis Outcome Score knee pain (KOOS KP), frequency, severity, and Quality of Life (QoL), frequent knee pain, knee pain severity, SF12 Mental Health and Physical Health subscales, physical activity, depression, 20-meter walk and chair stands). Combinations of these were evaluat

SUBMITTER: Kwoh CK 

PROVIDER: S-EPMC12448240 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature