Shockwave-driven activation of endoplasmic reticulum stress in osteoblasts to enhance bone formation under osteoporotic conditions.

ABSTRACT: Extracorporeal shockwave (ESW) therapy is a noninvasive physical intervention widely applied in orthopedics for the treatment of musculoskeletal disorders such as plantar fasciitis, osteoarthritis, delayed fracture healing and tendinopathies. In recent years, accumulating evidence has suggested that ESW may also have beneficial effects on bone regeneration and local bone mineral density, particularly under osteoporotic conditions. However, the precise biological mechanisms underlying these effects remain incompletely elucidated. In this study, we systematically investigated the effects of different radial extracorporeal shockwave (r-ESW) intensities on osteoblasts derived from osteoporotic bone (OPOB), with a specific focus on osteogenic activity and the involvement of endoplasmic reticulu

SUBMITTER: Luo D 

PROVIDER: S-EPMC12448281 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature