EPSD 2.0: An Updated Database of Protein Phosphorylation Sites Across Eukaryotic Species.

ABSTRACT: As one of the most crucial post-translational modifications, protein phosphorylation regulates a broad range of biological processes in eukaryotes. Biocuration, integration, and annotation of reported phosphorylation events will deliver a valuable resource for the community. Here, we present an updated database, the eukaryotic phosphorylation site database 2.0 (EPSD 2.0), which includes 2,769,163 experimentally identified phosphorylation sites (p-sites) in 362,707 phosphoproteins from 223 eukaryotes. From the literature, 873,718 new p-sites identified through high-throughput phosphoproteomic research were first collected, and 1,078,888 original phosphopeptides together with primary references were reserved. Then, this dataset was merged into EPSD 1.0, comprising 1,616,804 p-sites within 20

SUBMITTER: Chen M 

PROVIDER: S-EPMC12448286 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature