Mechanically reinforced core-shell scaffold with integrated structure and function for accelerated tendon repair.

ABSTRACT: Core-shell scaffold designs that mimic the biophysical structure of tendon extracellular matrix offer unique advantages for tendon repair. However, balancing the structural integrity of the scaffold with the desired material and biological properties remains challenging, limiting the effectiveness of the scaffold. Here, we present a new method for fabricating a core-shell scaffold with tailored properties for tendon tissue engineering. The scaffold core, designed for cell guidance, was created using direct ink writing, resulting in a helically interconnected fibre structure with controllable anisotropy and pore sizes. The mechanically reinforced shell, produced through uniaxial cold stretching of a laser-drilled sheet, featured microsurface ridges and through-hole arrays. The core-shell in

SUBMITTER: Long X 

PROVIDER: S-EPMC12448295 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature