Radiation impacts on toxicity of cobalt-chromium (CoCr) implant debris.

ABSTRACT: Particulate and soluble debris are generated by mechanical and non-mechanical degradation of implanted medical devices. Debris containing cobalt and chromium (CoCr) is known to cause adverse biological reactions. Implant-related complications are often diagnosed using radiography, which results in more frequent patient exposure to ionizing radiation. The aim of this study was to evaluate the potential for increased toxicity due to combined radiation and CoCr exposure. This was investigated using a controlled in vitro model consisting of commercially available CoCr debris that was generated from components of hip replacements and human cell lines relevant to the joint environment: endothelial HMEC-1 and synovial SW982. Particle sizes and shapes were heterogenous. Cells tended to inte

SUBMITTER: Trout KL 

PROVIDER: S-EPMC12448324 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature