Thiazole-carboxamide derivatives as potent antioxidant agents with drug-like properties: In vitro, molecular docking, and DFT studies.

ABSTRACT: The search for novel therapeutic agents with potent antioxidant and antidiabetic properties remains a critical area of research in medicinal chemistry. Oxidative stress, caused by an imbalance between free radicals and the body's antioxidant defenses, is implicated in numerous diseases, including diabetes, cancer, and neurodegenerative disorders. The in vitro evaluation of the antioxidant activity and α-amylase inhibitory potential was conducted on a series of thiazole-carboxamide derivatives, among this series, the strongest antioxidant activity against the DPPH free radical was exhibited by LMH6, with an IC₅₀ value of 0.185 µM, followed by LMH7 with an IC₅₀ value of 0.221 µM. Notably, the positive control Trolox exhibited a comparatively higher IC₅₀ value of 3.10 µM, underscoring the exc

SUBMITTER: Hawash M 

PROVIDER: S-EPMC12448349 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature