Examination of unique volatile organic compound signatures in nasopharyngeal test swab viral transport media using an electronic nose.

ABSTRACT: Rapid point of care tests for respiratory infections are associated with high rates of false negative results which can drive empiric, and potentially inappropriate, antibiotic use. Because infectious pathogens alter VOC composition, unique VOC signatures in biospecimens hold the potential to discriminate bacterial and viral infections from uninfected controls. One approach for rapid identification of respiratory pathogens is the electronic nose (e-nose), a sensor device that uses artificial intelligence to recognize disease-specific patterns in VOC profiles of gaseous mixtures. In this preclinical proof of concept study, we tested the validity of an e-nose to discriminate PCR-confirmed cases of infection with three viral pathogens (SARS-CoV-2, RSV, influenza A) from uninfected controls us

SUBMITTER: Swanson B 

PROVIDER: S-EPMC12448360 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature