The global and regional burden of early-onset gastric cancer (15-49 years, 1990-2021): incidence and mortality with projections to 2030.

ABSTRACT:

Background

While global gastric cancer incidence has declined, trends in early-onset gastric cancer (EOGC, age 15-49) remain unclear. This study evaluates EOGC's global burden (1990-2021), projects trends to 2030, and identifies epidemiological drivers.

Methods

Using Global Burden of Disease (GBD) 2021 data, we analyzed age-standardized incidence, mortality, disability-adjusted life years (DALYs), and estimated annual percentage change for EOGC globally and by sex, region, and income level. A Bayesian age-period-cohort model and decomposition analysis assessed temporal trends, epidemiological drivers (eg, aging, population growth), and projected burden through 2030.

Results

In 2021, EOGC caused 125 120 new cases and 78 871 deaths globally. From 1990 to 2021, age-stand

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12448411 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature