Interleukin-8 as a potential prognostic biomarker in renal cell carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Background and objective

Interleukin-8 (IL-8) is a chemokine involved in inflammation and primary immune response, playing a key role in recruiting neutrophils. IL-8 is produced by several cell types, including immune cells and certain cancer cells. Elevated levels of IL-8 have been associated with a poorer outcome in several tumors and have been related to advanced diseases, treatment resistance, and possibly promoting neo angiogenesis and immune cell recruitment. In the renal cell carcinoma (RCC), the prognostic role of IL-8 has not been settled.

Methods

From January 1, 2008 to June 18, 2024, PubMed, Embase, and Scopus databases were searched for all studies investigating the potential prognostic role of IL-8 in RCC. All studies were rated according to the Newcastle-Ottawa

SUBMITTER: Zacchi F 

PROVIDER: S-EPMC12448429 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature