Outcomes of Outpatient Advanced Therapy Exposed Patients Hospitalized With Severe Ulcerative Colitis.

ABSTRACT:

Background

Contemporary characteristics of hospitalized patients with ulcerative colitis (UC) may differ from historic standards in terms of prior drug exposure and disease severity. The impact of these differences on outcomes is unclear. This study aimed to assess inpatient UC outcomes according to prior outpatient drug exposure and measures of disease severity.

Methods

This was a multicenter, retrospective study of adult patients (age ≥ 18 years) hospitalized for severe UC. The primary outcome was the colectomy rate among outpatient advanced therapy exposed (ATE) vs advanced therapy naïve (ATN) patients. Secondary outcomes included length of hospitalization and need for rescue medical therapy.

Results

A total of 370 patients were included with 86 (23%) in the ATE gr

SUBMITTER: Al-Bawardy B 

PROVIDER: S-EPMC12448430 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature