A comparison of drugs targeting the renin-angiotensin system and global cognition in aging.

ABSTRACT: BackgroundHypertension (HTN) is a major risk factor for Alzheimer's disease (AD) and related dementias. Renin-angiotensin system (RAS) medications, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), have been proposed to mitigate cognitive decline, but evidence remains inconsistent.ObjectiveCompare global cognition over time among ARB, ACEI, and non-RAS drug users.MethodsData from the Rush Memory and Aging Project (1997-2006) included 2019 participants. Global cognition was assessed using a composite z-score of 19 cognitive tests. Participants were categorized by medication use: ARB, ACEI, or non-RAS. Analysis of covariance (ANCOVA) was performed to compare cognitive outcomes over 9 years, adjusting for baseline cognition, social determi

SUBMITTER: George CJ 

PROVIDER: S-EPMC12448431 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature