Association between estimated glucose disposal rate and testosterone level in US adult men: insights from NHANES 2013-2016.

ABSTRACT:

Background

Emerging evidence suggests that insulin sensitivity plays a role in testosterone regulation. The estimated glucose disposal rate (eGDR) is a validated metabolic marker reflecting insulin resistance (IR). However, the relationship between eGDR and testosterone levels in adult men remains unclear.

Aim

This study aimed to examine the association between eGDR, total testosterone (TT) levels, and testosterone deficiency (TD) risk.

Methods

Data from the 2013-2016 National Health and Nutrition Examination Survey (NHANES) were analyzed. Weighted multivariable linear and logistic regression models were used to evaluate the association between eGDR, TT levels, and TD risk (TT <300 ng/dL). A smoothing spline curve fitting approach was applied to assess the shape of th

SUBMITTER: Bian H 

PROVIDER: S-EPMC12448460 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature