Efficacy of Primaquine for the Radical Cure of Plasmodium vivax Malaria in Northeast Myanmar and the Impact of Cytochrome P450 2D6 Genotypes.

ABSTRACT:

Background

The antirelapse activity of primaquine (PQ) for Plasmodium vivax malaria depends on the host cytochrome P450 2D6 (CYP2D6) enzyme activity. This study aimed to assess the efficacy of PQ for the radical cure of P. vivax malaria in the Greater Mekong Subregion and determine the association of the post-PQ recurrences with CYP2D6 genotypes.

Methods

In 2014-2017, a total of 239 patients with uncomplicated P. vivax malaria in northeastern Myanmar were prospectively enrolled to receive a standard regimen of 3-day chloroquine and 14-day low-dose PQ (total dose, 3.5 mg/kg) as directly observed therapy. Patients were followed up biweekly for 1 year. A nested case-control study was designed to compare 49 patients with P. vivax malaria recurrences and 49 without recurrence. Th

SUBMITTER: Zeng W 

PROVIDER: S-EPMC12448580 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature