Plasma Reactive Dicarbonyls Are Not Independently Associated With Arterial Stiffness: The Maastricht Study.

ABSTRACT:

Background

Arterial stiffness is a strong predictor of cardiovascular diseases and all-cause mortality. Increased concentrations of highly reactive dicarbonyl compounds-methylglyoxal (MGO), glyoxal (GO), and/or 3-deoxyglucosone (3-DG)-may cause arterial stiffening via formation of advanced glycation end products, triggering maladaptive responses in vascular tissue, e.g., elastin degradation and collagen cross-linking. Therefore, we investigated in the population-based Maastricht study whether plasma MGO, GO, and 3-DG concentrations were cross-sectionally associated with carotid-to-femoral pulse wave velocity (cfPWV) and local carotid stiffness measures: pulse wave velocity (cPWV), and Young's elastic modulus (cYEM) using standardized main variables.

Methods

Fasting dicarbony

SUBMITTER: van der Bruggen MM 

PROVIDER: S-EPMC12448583 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature